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Brain cancer cases
Case 1: Oligodendroglioma-glioblastoma
Pathology
Name: Sirvart Doganian de Topalian
Age: 74 years old
Country: Brazil
Reason of consultation:
Brain tumor
Personal antecedents:
No personal antecedents to remark.
Family antecedents:
No family antecedents to remark.
Present disease antecedents:
On 09/02/1999: she has a cranial CAT done which shows
as a conclusion a left frontal expansive lesion. Front-parietal
expansive process, whose nature is to be clarified.
On 06/15/1999: she has a magnetic nuclear resonance
done which shows left frontal expansive lesion that
presents heterogenic aspect and irregular contours,
observing hyper-signal areas in T1 and hypo-signal in
T2. Suggesting blood component, signs of peri-lesional
edema, there is expansive effect characterized by erasing
of the adjacent lines and compression of the left lateral
ventricle, with slight deviation of the middle line
structures. This lesion measures approximately 4 cm.
Of diameter. The conclusion is that the magnetic nuclear
resonance aspect is of a left frontal blastomatose process
of probable glial origin.
09/26/1999: She has another cranial CAT done that does
not show significant changes considering the previous
ones.
On 09/28/1999: By per-surgery biopsy is diagnosed primary
mixed brain malignant neoplasy, oligodendroglioma-glioblastoma.
On 12/23/1999: A new cranial computerized tomography
is done which shows: Signs of left frontal craniotomy,
hypo-atenuating area in left frontal area is observed,
in the borders of the craniotomy, which after the intra-venous
injection of yode contrast, produces annular highlighting.
Recidivism? Accentuation of cortical lines and fissures
and cerebella lines. Centro medial structures without
deviation relating the middle line. Slight expansion
of the supra-tentorial ventricular system. Post-surgery
control.
On 01/17/2000: A cranial magnetic resonance is done,
conclusion: left frontal lesion suggesting glial originated
lesion, in relation to the previous exam of 09/15/1999
a reduction of the dimensions of the described lesion
is observed.
Observation: Signs of right maxillary sinusopathy and
bilateral sphenoidal.
On 05/26/2000: Encephalic magnetic resonance, conclusion:
post-surgery control of left frontal neoplasy, post-surgery
alterations with blood rests occupying the surgery remotion
cavity. Extended alteration of the sign of the white
substance of the brain hemispheres, of unspecific nature,
maybe representing gliosis, de-mielinization associated
to micro-angiopathies, not being possible to exclude
post-actinic leuco-encephalopathy if the patient underwent
radiotherapy. Gliosis focuses and/or ischemic lagoons,
and/or peri-vascular spaces extended in lentiform nucleus,
caudated, internal capsules and sub-insular regions.
Cortico-subcortical encephalic volumetric reduction.
Disease evolution:
She begins to take GREEN SAP drops at a dosage of 40
drops, 6 times per day in August, 2000.
On 08/31/2000: An encephalic magnetic resonance is done
which shows, conclusion: post-surgery control, blood
rests occupying surgery remotion area with smaller dimensions
in relation to the last exam with no evidences of local
recidivism.
The rest of the findings did not alter significantly
from the last study.
On 01/30/2001: An encephalic magnetic resonance is done
which shows: conclusions: Post-surgery control exam
of left frontal neoplasy, in relation to the previous
exam (from 08/31/2000) it is noted a reduction of the
dimensions of the blood content and the contrast associated
of the medium left frontal lesion and in correspondence
to the surgery layer. Slight increase of the extension
of the diffuse signal alteration in the white substance
of the brain hemispheres, of unspecific significance.
If there has been radiotherapy post-actinic leuco-encephalopathy
has to be the first diagnose consideration.
On 04/27/2001: Encephalic magnetic resonance, in relation
to the previous exam of 01/30/2001, there are evidences
of partial absorption of the blood rests, which are
situated in the surgery layer, as well as of the associated
residual contrast; with other findings practically unaltered.
No evidences of local neoplasic recidives have aroused.
On 09/04/2001: Cranial magnetic resonance, conclusions:
Analysis: Signs of left frontal craniotomy, slight expansion
of the supra-tentorial ventricles, without hypertensive
characteristics, slight expansion of the IV ventricle,
slight accentuation of cortical lines and fissures and
of the basal cisterns. Excepting for lines in the left
frontal region, which are partially fainted. Diffuse
hypersignal in T2, and Flair in the white substance
bilaterally compatible with leuko-encephalopathy.
Presence of magnetic susceptible articles in the craniotomy
area which may give partly the adjacent structures image.
On 08/14/2002: Cranial magnetic resonance, showed: left
frontal craniotomy, with presence of slight irregular
areas of post-contrast highlighting, besides the surgery
layer, less evident in the present study.
Magnetic susceptible artifacts adjacent to the craniotomy.
Peri-vascular spaces extended. There persist extended
areas of signal alteration, characterized by a high
sign in T2 and Flair that does not present post-contrast
highlighting, compromising the white substance of both
brain hemispheres. Suggesting post-actinic alterations.
The rest of the encephalic parenchyma with normal sign
intensities. Crane-vertebral transition without abnormalities.
Extended cortical lines. Big Silvian caesuras and basal
cisterns. Dilatation of the supra-tentorial ventricular
system, IV ventricle with normal form and dimensions.
Comparatively to the previous exam, reduction of the
extension and intensity of the signals of the post-contrast
highlighting areas was observed adjacent to the left
frontal craniotomy.
Cranial magnetic resonance was made on 01/02/2003, which
shows: left frontal post-surgery status. The comparative
analysis of the present exam to that of the previous
one no significant alterations are observed. Irregular
contrast focus in the left frontal white substance which
can correspond to a gliosis focus but does not discard
recidivism signs. Increase of the encephalic liquid
spaces. Signs of micro-leuko-angiopathy, peri-ventricular
and in semi-oval centers.
We must remark that the patient received in all this
period GREEN SAP drops as medicament, finding herself
as it arises from the imagenologic results, stable since
2 years and a half ago with the intake of the medicament.
Although the tumor extirpation was performed we think
that this therapy alone does not justify the excellent
evolution she had afterwards, reason why we consider
her asymptomatic in clinic cure, receiving maintenance
dosage of the medicament.
Conclusions:
It is about a patient of 74 years
old at present, with a brain malignant neoplasy of ominous
prognosis. This neoplasy was extirpated, turning out
to be a oligodendroglioma-glioblastoma, the patient
in the 2000 begins to take the medicament, maintaining
unchanged the imagenology and with a tendency to reduction.
GREEN SAP evidently acted crossing the hemato-encephalic
barrier as we stated in the central nervous system GREEN
SAP anti-tumor action. This appears evident by the excellent
result achieved as in the other cases already referred.
This is why that a direct GREEN SAP action on the tumor
is observed, although before we did not have the experience
we nowadays have and was stated that GREEN SAP could
not cross the hemato-encephalic barrier as well as many
other medicaments.
Nowadays, with the acquired experience and the results
achieved by the patients, we firmly think that GREEN
SAP has a very well deserved position in the treatment
of the Central Nervous System tumors, obtaining remissions,
stabilizations and clinic cures. It is remarkable that
no endo-cranial hypertension syndrome has produced,
and this would be related to the mass effect taken away
by the surgery, but also to the anti-inflammatory and
stabilization effect of GREEN SAP.
This is a case that fills us with proud. The use of
our medicament, which has already been proved by time
and the empiric experience, has led a very difficult
prognosis patient, even with the more modern conventional
techniques, to a state of health. At the present moment
she is in cure and can perform the tasks that other
people of her age develop. GREEN SAP is a medicament
of proven efficacy, even in so dangerous diseases and
recommendable in oncology pathology. We can affirm this
medicament is a so fortunate finding from the medical
point of view that enables us to have such rewards as
the one offered by this patient. This medicament is
not an improvisation and hundreds of cases all around
the world testify so. It creates hope where there is
hopelessness, creates strength where the body and the
soul weak and from the medical point of view achieves
a percentage of cure that plenty justifies what we previously
said.
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