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Mechanism's Action
GREEN SAP acts in this way:
a) Inhibition of tumor cell's growth up.
b) Cause programmed cell death (apoptosis).
c) Acts as immune modulator.
Other studies with GREEN SAP's components in south American
countries and Europeans in citotoxicity essays determined
interactions of them with tumor cell's DNA (prooxidation
of it) and some favorable results in leukemia (Arizona,
M. et al., 1985; Jorbis B. et al., 1988, Mongelli E.
et al., 1996).
Between biologic activities demonstrated
by GREEN SAP it can be mentioned at digestive level
antiulcer activity in induced-ulcer models by Indometacina
which action's mechanism will center in a minor mobilization
of calcium at intracellular level (Gamberini y Lapa
A. 1992) and hepatoprotective action and colagogue demonstrated
by their flavonoids. The mixture of them demonstrated
to increase between 25 % and 100 % the percentage of
overlife in intoxicated rats with phalloidina in a dose
of 20 mg/kg intravenous.
The substance present in the components of the product
that resulted more active in antitumoral protection
was hispidulina according to Soickee H. y Leng Peschlow
E. 1987.
The synergism of the substances of the plants that conform
GREEN SAP, reach a marked antitumoral effect and besides
a marked colagogue and hepatoprotective effect.
The information about the component's
properties is complemented by the essays of cellular
kinetic made specifically with the product that allow
to prove its activity as tumor cell's growth up inhibitor
and observations at microscope at them that showed signals
of cellular death comparables with " programmed cellular
death " (apoptosis)
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